Synthetic Biology

Synthetic biology is an umbrella term that refers to powerful techniques for re-engineering the fundamental molecular structures of life, including genes, genomes, cells, and proteins. Some of the techniques being developed under this rubric enable the modification of existing bacteria to produce useful substances or perform new functions and the creation of novel artificial organisms, so far for research purposes. Synthetic biologists foresee a host of applications, including new methods for producing drugs, biofuels, and vaccines; diagnosing, preventing, and treating disease; and — far more controversially and far-off — synthesizing modified human genes to produce specified traits in future children and generations. Such eugenic visions raise concerns about social justice, human rights, and equality.

Environmentalists and populations near actual or proposed uses of synthetic biology products have voiced concerns about ecological and biosecurity risks. These are especially acute when synthetic biology techniques are combined with “gene drives,” which can enable the rapid spread of modified organisms through the natural population. At present, no comprehensive framework for assessment, oversight, and regulation of synthetic biology exists nationally or internationally.


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In Burkina Faso, the government is considering the use of genetically modified mosquitoes to eradicate malaria. In Nantucket, Mass., officials are looking at gene editing as a tool in the fight against Lyme disease. And scientists are using gene technology...

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In 1985, the chemist Steven A. Benner sat down with some colleagues and a notebook and sketched out a way to expand the alphabet of DNA. He has been trying to make those sketches real ever since.

On Thursday, Dr....

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New genetic tools are making it easier and cheaper to engineer viruses and bacteria, and a report commissioned by the...

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Researchers have rendered a population of mosquitoes in a lab sterile using the gene-editing tool CRISPR-Cas9 by homing in on...

Human embryo under a microscope on blue background

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Blue DNA on black background with green vertical letters and numbers on top

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Double helix strand of DNA with backbone that is orange and bases that are green

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