Developing an international framework for stem-cell-based embryo models

The ability of pluripotent stem cells to differentiate into different cell types has enabled the creation of stem-cell-based embryo models (SCBEMs), which have the potential to illuminate the early stages of embryo development and implantation. SCBEMs hold promise as an avenue to address global health challenges including infertility, pregnancy loss and the need for organ transplants, as well as congenital, neonatal and adult health conditions.

In addition to answering existing scientific questions and raising new scientific questions, SCBEMs pose practical, ethical and legal questions that also need to be addressed. Following a meeting of researchers at the Institut Pasteur in Paris in November 2024, we have been working with colleagues around the world to develop a foundational framework for research, technological development and regulation in relation to SCBEMs.

Some of our key recommendations are set out below, grouped into three sections – 'Science and standards', 'Technologies and applications' and 'Ethics and law'. These matters are explored at greater length in our full white paper, and we have also set out proposals for...