What Is the World to Do About Gene-Editing?
By Stephen Buranyi,
The New York Review of Books
| 03. 21. 2019
When the journal Science chose the radical gene-editing technology CRISPR as its 2015 breakthrough of the year, the editorial team closed its description on a dire note. “For better or worse, we all now live in CRISPR’s world,” they wrote. Emerging into the public consciousness in 2013, CRISPR has been with us only as long as it takes to complete secondary school, but like the information technologies that rose alongside it, it is often described as if it is beyond regulation and direction, as if it had acquired its own uncompromising telos.
CRISPR works by repurposing parts of an ancient bacterial immune system to make the job of editing genes in almost any organism unprecedentedly simple and accurate. So simple, in fact, that unlike other scientific advancements that are perpetually just around the corner, CRISPR entered widespread use almost immediately. Gene-edited mice and zebrafish, classic laboratory models, rapidly gave way to edits in the genomes of livestock such as pigs and cows. Chinese scientists have been running human gene-editing trials since 2016, and the first stateside trials for CRISPR in...
Related Articles
By Laura DeFrancesco, Nature Biotechnology | 03.17.2026
The first gene editors designed to fix genetic lesions in mutation-agnostic ways are poised to enter the clinic. Tessera Therapeutics and Alltrna, two Flagship Pioneering-funded companies, are gearing up to test novel genetic medicines in humans. Tessera received regulatory clearance...
By Darren Incorvaia, Fierce Biotech | 03.11.2026
A new method for safely inserting large chunks of DNA into genomes has now measured up in mice, potentially paving the way for the next generation of gene editing medicines.
The approach, which is described in a Nature paper...
By Jason Liebowitz, The New Yorker | 03.06.2026
When Talaya Reid was in high school, in a quiet suburb of Philadelphia, she developed fatigue so severe that she spent afternoons napping instead of going out with friends. She was lethargic at school and her grades suffered, but after...
By Scott Solomon, The MIT Press Reader | 02.12.2026
Chris Mason is a man in a hurry.
“Sometimes walking from the subway to the lab takes too long, so I’ll start running,” he told me over breakfast at a bistro near his home in Brooklyn on a crisp...