Is a therapy designed to treat mitochondrial disease setting its sights on age?
By Alison Motluk,
HeyReprotech [cites CGS' Marcy Darnovsky]
| 04. 30. 2019
Mitochondria provide the power for our cells, and when they malfunction, it can be serious. So scientists have developed experimental treatments that use healthy mitochondria from donor eggs.
In one variation, the nuclear DNA is removed from a donor egg and replaced with the nuclear DNA from an intended mother's egg; the donor egg's mitochondria, left behind in the cytoplasm, provide the power pack. The egg is then fertilized. In another variation, both an egg from a donor and an egg from the mother are fertilized before that swap takes place. Almost all of a person's DNA is in the nucleus, and almost all traits are determined by this nuclear DNA, but mitochondria also contain a small amount of DNA. This means that any child born from such a therapy will inherit DNA from three people — the mother, the father and the donor — which has given rise to terms like 'three-person IVF' and 'three-parent baby.'
The treatments have been controversial since the outset, because it's not yet known whether there will be unintended side effects. It's not easy...
Related Articles
By Carl Zimmer, The New York Times | 06.04.2026
Scientists at Columbia University have edited the DNA of early human embryos with unprecedented accuracy, an achievement that could open the way to babies engineered with particular characteristics.
The prospect has fueled controversy for years. On the one hand, the...
Faster, Higher, Stronger was the Olympic motto from 1874 until 2001, when “ – Together” was added, to stress the “moral and educational perspective” of the Games. The folks who paid for or participated in the Enhanced Games – the name itself a nod to the Olympics – held in Las Vegas on Sunday, May 24, apparently use a different edit:
Faster, Higher, Stronger with Chemistry
High-level sport draws huge crowds. Coming very soon, the soccer World Cup, featuring...
By Gina Kolata, The New York Times | 05.25.2026
In a small, preliminary study, an experimental gene-editing treatment dramatically lowered cholesterol levels, perhaps permanently, after just one infusion, scientists reported on Monday.
If confirmed in larger studies, researchers hope the findings may lead to a one-and-done way to prevent...
By Ryan Cross, Endpoint News | 05.20.2026
BOSTON — Over the past year, I’ve begun hearing rumblings from scientists who secretly think it’s time to stop being stodgy about editing the genes of human embryos.
For the most part, they are still too timid to speak up...