Single-Cell Genomics Could Improve IVF Screening
        
            By Susan Young, 
                MIT Technology Review
             | 11. 05. 2013
        
                    
                                    
                    
                                                                                                                                    
                                                                            
                              
    
  
  
    
  
          
  
      
    
            Fertility doctors in Beijing have begun testing a new method for genome analysis of human eggs before using them for in vitro fertilization or IVF. The tests, using technology developed by a Harvard chemist, allow doctors to know the genome of a woman’s egg before it is used in IVF, which could provide a safer way to help their patients avoid genetic disorders in children.
The test is part of a larger effort by researchers to develop techniques to sequence the genomes of single cells. In some medical situations, such as when examining the scarce cancer cells that can be found in some patients’ blood (see “
Finding Cancer Cells in the Blood”), doctors have only a tiny amount of genetic material to work with and so must use specialized techniques to prepare samples for DNA sequencing.  
Researchers are also exploring single-cell-genomics techniques as part of screening tests in fertility clinics. Genetic analyses that are more limited than whole-genome sequencing are already widely performed on IVF embryos by plucking a single cell from an embryo to determine the...
 
 
  
 
    
    
  
   
                        
                                                                                
                 
                                                    
                            
                                  
    
  
  
      Related Articles
    
  
          
  
  
  
  
  
  
      
            
                  
  
      
    
    
                
                        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                           By Abby McCloskey,  The Dallas Morning News | 10.10.2025
                                                        
     
    
    
            We Texans like to do things our way — leave some hide on the fence rather than stay corralled, as goes a line in Wallace O. Chariton’s Texas dictionary This Dog’ll Hunt. Lately, I’ve been wondering what this ethos...
 
       
 
 
  
      
    
    
    
    
            Paula Amato & Shoukhrat Mitalipov
[OHSU News/Christine Torres Hicks]
On September 30th, a team of 21 scientists from Oregon Health & Science University (OHSU) published a significant paper in Nature Communications, with a scientifically accurate but, to many, somewhat abstruse headline:
Induction of experimental cell division to generate cells with reduced chromosome ploidy
The lead authors were Shoukhrat Mitalipov, recently described here as “a push-the-envelope biologist,” and his long-term colleague Paula Amato. (Recall that in July the pair had co-published with...
 
       
 
 
  
      
    
    
                
                        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                           By Julia Black,  MIT Technology Review | 10.16.2025
                                                        
     
    
    
            Consider, if you will, the translucent blob in the eye of a microscope: a human blastocyst, the biological specimen that emerges just five days or so after a fateful encounter between egg and sperm. This bundle of cells, about the size of...
 
       
 
 
  
      
    
    
                
                        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                           By Lizzy Lawrence,  Stat News | 10.14.2025