The National Institutes of Health recently announced a remarkable achievement: the world’s largest database of human genomes, a repository of information that the agency says will help usher in a new era in personalized medicine.
Scientists are already developing clinical tools and techniques based on genomic information gathered from the agency’s All of Us program. One of the most promising? Polygenic risk scores. These can help predict a person’s likelihood of developing complex diseases, like cardiovascular disease and breast cancer, from as early as infancy.
But there’s a glaring problem: The tools were trained overwhelmingly on the DNA of people of European descent, so they often fail to accurately assess risks for anyone else. For some conditions, the forecasts for people of color are almost no better than flipping a coin.
Researchers are racing to correct the biases through advancements in modeling and widespread recruitment of minority groups. They fear that failing to close the gaps could worsen health care disparities — and prevent the technology from realizing its promise of helping to decrease chronic disease.
What We Inheritby Sam Trejo and Daphne O. Martschenko; andOriginal Sin by Kathryn Paige Harden have a great deal in common, with substantial differences in style and emphasis. Both books attempt, in different ways, to show the reader just where current research into human genomics stands, where that might be going, and why the authors are interested. In short, the influence of genomic research on our societies is already large and seems likely to change them in ways...
The pseudoscience of eugenics, founded on the mistaken notion that nature envisions some “right” combination of genes, and that selective breeding can improve the human race, is making a comeback. While the heyday of eugenics was a century ago, the...
NEW YORK (AP) — Matt Walker couldn’t pet a dog without sneezing — until he and other scientists used a gene editing technique to produce a hypoallergenic beagle named Bailey.
The young girl tugged on her mother’s hand as they pressed through the doors of the hospital in Shanghai. She was 6 years old, bouncing along in a pink jacket and blue pants decorated with cartoon bears. Behind them, her...
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