Human Germline and Heritable Genome Editing: The Global Policy Landscape
By Françoise Baylis, Marcy Darnovsky, Katie Hasson, and Timothy M. Krahn,
The CRISPR Journal
| 10. 20. 2020
Discussions and debates about the governance of human germline and heritable genome editing should be informed by a clear and accurate understanding of the global policy landscape. This policy survey of 106 countries yields significant new data. A large majority of countries (96 out of 106) surveyed have policy documents—legislation, regulations, guidelines, codes, and international treaties—relevant to the use of genome editing to modify early-stage human embryos, gametes, or their precursor cells. Most of these 96 countries do not have policies that specifically address the use of genetically modified in vitro embryos in laboratory research (germline genome editing); of those that do, 23 prohibit this research and 11 explicitly permit it. Seventy-five of the 96 countries prohibit the use of genetically modified in vitro embryos to initiate a pregnancy (heritable genome editing). Five of these 75 countries provide exceptions to their prohibitions. No country explicitly permits heritable human genome editing. These data contrast markedly with previously reported findings.
Development of the CRISPR genome editing technology in 2012–131,2 intensified the decades-long controversy on the likely social... see more
"Human Egg" by euthman is licensed under CC BY 2.0.
In late April, the National Academies held a three-day workshop on In Vitro Derived Human Gametes as a Reproductive Technology
. Experts from a broad range of fields commented on the fast-developing science, its potential applications in assisted reproduction, and its social implications. Despite a focus on the significant technical challenges that remain in developing these techniques and the notable inclusion of several critical voices, the overall...
By CGS Staff
On May 4, the Center for Genetics and Society contributed invited remarks about heritable gene editing at a comment session hosted by the National Council on Disability (NCD), the US federal agency that advises government and the private sector on disability policy. Some 17 speakers, including representatives of disability and patient advocacy organizations, scholars, medical researchers, and genetic counselors, weighed in for three minutes each on the topic “Germline editing, fetal medicine, and their impact on people with disabilities.”
Adapted from Mitochondrial DNA at
National Human Genome Research Institute
The Guardian reports that “a small number of babies” with DNA from three people have now been born in the UK. The exact number has not been disclosed; it is less than five but more than one. The Human Fertilisation and Embryology Authority (HFEA), the government agency that regulates the process, revealed that much in response to a freedom of information request, and noted in a rather terse statement that...
By Carolyn Y. Johnson, The Washington Post | 04.28.2023
DACULA, Ga. — For as long as he can remember, Jimi Olaghere felt he was destined to be a father. “It’s so true in my soul,” he told his wife, Amanda, when they struggled to get pregnant. But when they...