Drugs Don’t Work If People Can’t Afford Them: The High Price Of Tisagenlecleucel
By Paul Kleutghen, David Mitchell, Aaron S. Kesselheim, Mehdi Najafzadeh, and Ameet Sarpatwari,
HealthAffairs
| 02. 08. 2018
In a system in which life-saving drugs are developed with direct and indirect taxpayer support and afforded market protection through government-granted exclusivities, patients deserve to know how drug manufacturers are arriving at ever-higher prices for their products. Without such information—and subsequent policy reforms based on it—treatment will become increasingly unaffordable. Sadly, for many Americans, it already has; 21 percent of 1,204 respondents in a December 2016 Henry J. Kaiser Family Foundation survey reported that they or a family member did not fill a prescription in the past year because of cost.
Why Tisagenlecleucel Matters
One of the most recent examples highlighting the prescription drug price debate is the chimeric antigen receptor T-cell (CAR-T) immunotherapy tisagenlecleucel (Kymriah). Widely hailed as a groundbreaking treatment, it was approved by the Food and Drug Administration (FDA) in August 2017 for the treatment of pediatric and young adult acute lymphoblastic leukemia. In coming years, tisagenlecleucel is expected to receive marketing approval in other countries and for other indications, including adult acute lymphoblastic leukemia, chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and small lymphocytic lymphoma...
Related Articles
By Rob Stein, NPR | 09.30.2025
Scientists have created human eggs containing genes from adult skin cells, a step that someday could help women who are infertile or gay couples have babies with their own genes but would also raise difficult ethical, social and legal issues...
By Daniel Hildebrand, The Humanist | 10.01.2025
When most people hear the word eugenics, they think of dusty history textbooks and black-and-white photographs: forced sterilizations in the early 20th century, pseudoscientific charts measuring skulls, the language of “fitness” used to justify violence and exclusion. It feels like...
By Marianne Lamers, NEMO Kennislink [cites CGS' Katie Hasson] | 09.23.2025
Een rijtje gespreide vulva’s gaapt de bezoeker aan. Zó ziet een bevalling eruit, en zó een baarmoeder met foetus. Een zwangerschap, maar dan zonder zwangere vrouw, gestript van zorgen, gêne en pijn. De zwangerschapsmodellen en oefenbekkens, te zien in de...
By Auriane Polge, Science & Vie [cites CGS' Katie Hasson] | 09.19.2025
L’idée de pouvoir choisir certaines caractéristiques de son futur enfant a longtemps relevé de la science-fiction ou du débat éthique. Aujourd’hui, les technologies de séquençage et les algorithmes d’analyse génétique repoussent les limites de ce qui semblait encore impossible. Au croisement...