Beyond gene-edited babies: the possible paths for tinkering with human evolution

In 2016, I attended a large meeting of journalists in Washington, DC. The keynote speaker was Jennifer Doudna, who just a few years before had co-invented CRISPR, a revolutionary method of changing genes that was sweeping across biology labs because it was so easy to use. With its discovery, Doudna explained, humanity had achieved the ability to change its own fundamental molecular nature. And that capability came with both possibility and danger. One of her biggest fears, she said, was “waking up one morning and reading about the first CRISPR baby”—a child with deliberately altered genes baked in from the start.  

As a journalist specializing in genetic engineering—the weirder the better—I had a different fear. A CRISPR baby would be a story of the century, and I worried some other journalist would get the scoop. Gene editing had become the biggest subject on the biotech beat, and once a team in China had altered the DNA of a monkey to introduce customized mutations, it seemed obvious that further envelope-pushing wasn’t far off. 

If anyone did create an edited baby...