The slippery slope of the human gene editing debate
By John Evans,
Oxford University Press Blog
| 09. 22. 2020
The ethical debate about what is now called “human gene editing” (HGE) began sixty years ago. At the time, eugenicist scientists wanted to use new knowledge about the structure of DNA to modify humans—to perfect the human species by making us more healthy, musical, intelligent, and generally virtuous. A consensus later formed that gene editing on individuals to remove disease is acceptable, but nobody should try to change the human species. This is known as the somatic (individual) vs. germline (species) distinction, and it served as a moral limit on HGE for 50 years. A few years ago the news broke that a Chinese scientist had facilitated the creation of children who have been genetically modified so their descendants would also be modified—germline HGE. The germline limit now seems to be gone. Are there any limits left?
The HGE debate, like many bioethical debates, is set up like a slippery slope. At the top is an act universally considered morally virtuous (point A). Stepping on the slope at the top makes the act a little bit further down the slope...
Related Articles
By Carl Zimmer and Marco Hernandez , The New York Times | 07.01.2026
Scientists have long dreamed of discovering the alchemy by which chemicals can be turned into life. On Wednesday, a team at the University of Minnesota announced that it had taken a major step toward that vision.
Blending together dozens of...
By Michael Le Page , New Scientist | 06.25.2026
We now know the master gene that controls embryonic development in people. Called NANOG, its role has been identified by making precise changes to the DNA of fertilised eggs using a technique called CRISPR base editing.
The discovery might lead...
By Editorial Staff, The Guardian | 07.05.2026
Ever since Crispr-Cas9 gene-editing technology emerged in the early 2010s, ethical questions around genetically altered humans, so-called designer babies, have become increasingly urgent. There is already a worldwide legal prohibition. No country currently allows human germline editing (meaning genetic changes...
By Sarah Norcross, Sandy Starr, Amanda Cooney, and Anneliese Burton, BioNews | 07.06.2026