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Children born after IVF treatment have a greater risk of complications ranging from preterm birth to neonatal death, according to a major study into the health of newborns.

Doctors found that single IVF babies were nearly twice as likely to be born early, to be stillborn, or to die within the first 28 days of delivery compared with those conceived naturally.

But the study, based on more than 300,000 births in South Australia between 1986 and 1992, did not look at whether IVF treatment was to blame, and leaves open the possibility that the IVF babies fared worse for other reasons, such as health problems, or older age, that caused couples to be infertile in the first place.

"There is in all likelihood a contribution from both the treatment and patient factors," said Michael Davies, who led the study at the University of Adelaide. "We have very unfriendly work practices that mean families defer child-bearing until women are relatively old, and that is tragic."

The age of the medical records, with the most recent being from 2002, means they provide...