Three Parents and a Baby - Scientists Advise Caution with Regard to Artificial Insemination Method

The approval of a new treatment method by which three parents will be able to beget a child is being discussed since a few years in Great Britain and will possibly become a reality in two years. The method is supposed to help in eliminating the mother's genetic defects already in the test tube.

The defect lies in so-called mitochondria, the "power houses" of cells. To get rid of defective mitochondria the nucleus of one egg cell has to be transferred to another egg cell bearing intact mitochondria. Scientists at the Vetmeduni Vienna show for the first time that even a few defective mitochondria dragged along in the transfer could cause diseases. The results were published in Cell Reports.   

Mitochondria are cell organelles located within animal and human cells. They produce energy for the organism, possess their own genetic material - mitochondrial DNA (mtDNA) - and are transmitted exclusively by the mother. Depending on their activity and tasks, different numbers of mitochondria are present in a cell - usually a few hundred to a thousand per body cell.

Inherited mitochondrial...