Should We Alter the Human Genome? Let Democracy Decide
By Krishanu Saha, J. Benjamin Hurlbut & Sheila Jasanoff,
Scientific American
| 01. 15. 2020
We need greater scientific and moral clarity on germ line editing.
In November 2018, a Chinese scientist, He Jiankui, caused an international uproar by announcing the birth of two babies whose DNA he had edited using a tool called CRISPR-Cas9. Human germline genome editing—that is, making precise changes in human DNA that can be passed down through generations—has been seen for decades as a line that should not be crossed. This past December, He was sentenced to three years in prison for carrying out an “illegal medical practice.”
Yet, as the Chinese experiment shows, the state of technology no longer bars those who are willing to cross it. He’s experiment was a profound scientific and ethical misstep. Not only did he do it before adequate preparatory studies had been undertaken, but he acted unilaterally, deploying a technology with the potential to affect deeply held beliefs about human life all around the planet. His experiment set a dangerous example for other overly eager scientists. In mid-2019, a Russian scientist proposed a similar experiment.
We cannot blame lax oversight on China alone. The scientist who carried out the controversial first experiment in China...
Related Articles
By Laura DeFrancesco, Nature Biotechnology | 03.17.2026
The first gene editors designed to fix genetic lesions in mutation-agnostic ways are poised to enter the clinic. Tessera Therapeutics and Alltrna, two Flagship Pioneering-funded companies, are gearing up to test novel genetic medicines in humans. Tessera received regulatory clearance...
By Darren Incorvaia, Fierce Biotech | 03.11.2026
A new method for safely inserting large chunks of DNA into genomes has now measured up in mice, potentially paving the way for the next generation of gene editing medicines.
The approach, which is described in a Nature paper...
By Jason Liebowitz, The New Yorker | 03.06.2026
When Talaya Reid was in high school, in a quiet suburb of Philadelphia, she developed fatigue so severe that she spent afternoons napping instead of going out with friends. She was lethargic at school and her grades suffered, but after...
By Scott Solomon, The MIT Press Reader | 02.12.2026
Chris Mason is a man in a hurry.
“Sometimes walking from the subway to the lab takes too long, so I’ll start running,” he told me over breakfast at a bistro near his home in Brooklyn on a crisp...