Controversial ‘3-Parent Baby’ Fertility Technique Fails to Deliver for Older Women
        
            By Emily Mullin, 
                Medium One Zero [cites CGS' Marcy Darnovsky]
             | 10. 15. 2019
        
            The experimental procedure is banned in the United States but is being offered at clinics abroad as a treatment for infertility.
                    
                                    
                    
                                                                                                                                    
                                                                            
                              
    
  
  
    
  
          
  
      
    
            An experimental and much-hyped reproductive procedure that mixes DNA from three people is not effective at boosting the chances of having a baby for women ages 37 and older, according to doctors at a fertility clinic in Ukraine.
The technique, known as mitochondrial replacement therapy, involves taking a woman’s egg and shifting the majority of its DNA, known as the nucleus, into a hollowed-out donor egg. The shell of the donor egg contains healthy mitochondria, energy-making structures that have their own DNA. The resulting embryo ends up with DNA from the mother, father, and egg donor, so the technique is often referred to as “three-person IVF.” The procedure is controversial because many consider it a form of genetic manipulation.
Some fertility experts hoped that the younger mitochondria from the hollowed-out donor egg might rejuvenate the eggs of an infertile woman, thus increasing the chances of a successful pregnancy.
But new study results presented at a meeting of the American Society of Reproductive Medicine in Philadelphia show that might not be the case. The three-person IVF procedure was found to be...
 
       
 
  
 
    
    
  
   
                        
                                                                                
                 
                                                    
                            
                                  
    
  
  
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[OHSU News/Christine Torres Hicks]
On September 30th, a team of 21 scientists from Oregon Health & Science University (OHSU) published a significant paper in Nature Communications, with a scientifically accurate but, to many, somewhat abstruse headline:
Induction of experimental cell division to generate cells with reduced chromosome ploidy
The lead authors were Shoukhrat Mitalipov, recently described here as “a push-the-envelope biologist,” and his long-term colleague Paula Amato. (Recall that in July the pair had co-published with...
 
       
 
 
  
      
    
    
                
                        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
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First, a doctor inserted a needle into his back to...
 
       
 
 
  
      
    
    
                
                        
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
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