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genome sequencing against disease

Sitting in their toy-filled family room on a sunny September afternoon, Simone and Malcolm Collins were forced to compete with the wails of two toddlers as they mapped out their plans for humankind.

"I do not think humanity is in a great situation right now. And I think if somebody doesn't fix the problem, we could be gone," Malcolm half-shouted as he pushed his sniffling 18-month-old, Torsten, back and forth in a child-size Tonka truck.

Along with his 3-year-old brother, Octavian, and his newborn sister, Titan Invictus, Torsten has unwittingly joined an audacious experiment. According to his parents' calculations, as long as each of their descendants can commit to having at least eight children for just 11 generations, the Collins bloodline will eventually outnumber the current human population. 

If they succeed, Malcolm continued, "we could set the future of our species."

Malcolm, 36, and his wife, Simone, 35, are "pronatalists," part of a quiet but growing movement taking hold in wealthy tech and venture-capitalist circles. People like the Collinses fear that falling birth rates in certain developed countries like the...