The beautiful science of embryology
By Kate Womersley,
Prospect
| 03. 03. 2021
It’s a familiar story: the virile sperm fights its path through the hostile uterus to the passive female egg. After fertilisation, the resulting ball of cells is “totipotent,” with each unit equally capable of becoming any cell type in the placenta or foetus. Magdalena Zernicka-Goetz, an embryologist from the University of Cambridge, affronted her field by claiming this was wrong: not just the sexist metaphors, but also the assumption that the first human cells are identical. Her experiments showed that cells lean towards a particular fate, and that an embryo’s symmetry is broken from its earliest moments.
Together with science journalist Roger Highfield, Zernicka-Goetz leads us through the intricacies of modern embryology and reproductive technology. Her successes include doubling the length of time embryos can survive in the lab, building simulation mouse embryos out of stem cells and using fluorescent labels to make “embryo art.” “We are entering a new era,” she writes, “one where we can manipulate the cellular units of life as skilfully as a potter works clay.” While gene editing and designer babies raise understandable alarm, artistry...
Related Articles
By Laura DeFrancesco, Nature Biotechnology | 03.17.2026
The first gene editors designed to fix genetic lesions in mutation-agnostic ways are poised to enter the clinic. Tessera Therapeutics and Alltrna, two Flagship Pioneering-funded companies, are gearing up to test novel genetic medicines in humans. Tessera received regulatory clearance...
By Darren Incorvaia, Fierce Biotech | 03.11.2026
A new method for safely inserting large chunks of DNA into genomes has now measured up in mice, potentially paving the way for the next generation of gene editing medicines.
The approach, which is described in a Nature paper...
By Jason Liebowitz, The New Yorker | 03.06.2026
When Talaya Reid was in high school, in a quiet suburb of Philadelphia, she developed fatigue so severe that she spent afternoons napping instead of going out with friends. She was lethargic at school and her grades suffered, but after...
By Scott Solomon, The MIT Press Reader | 02.12.2026
Chris Mason is a man in a hurry.
“Sometimes walking from the subway to the lab takes too long, so I’ll start running,” he told me over breakfast at a bistro near his home in Brooklyn on a crisp...