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A pair of advocates—they do legitimate research too, but their ardor is so intense, it’s hard to call them scientists—believe that they will, within their lifetimes, make ours the first generation of humans to live forever.

Their quest is elegantly laid out in The Immortalists, a new documentary making its way around the film festival circuit. The Immortalists follows the triumphs and tragedies of three years in the lives of William H. Andrews and Aubrey de Grey, two men who prove just as interesting as the work they’re doing. The Immortalists is really a film about death, not life, which is what makes it so fascinating.

Here’s the trailer.

The goal of Andrews and de Grey is not merely to extend life, but to actually reverse the aging process. “Once we are really truly repairing things as fast as they go wrong, game over,” de Grey says in the film. “We will have the ability to live indefinitely.”

The mechanisms by which each man proposes to end death are radically different. Andrews suggests that in order to...