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Like most American women who give birth to a severely handicapped child, Donna Branca became pregnant with A.J. well before the age of 35. Had she been older, her doctors would almost certainly have recommended amniocentesis to screen for genetic disorders. But she was 31, so they did not, despite the fact that she had an unusual pregnancy. Branca bled during her first trimester, a possible indication of birth defects, and at her midterm sonogram, when she was 20 weeks pregnant, her fetus looked smaller than it should have based on when her doctors originally presumed she conceived. Branca had not gained much weight, either, but her doctors _ whom she is barred from identifying, by a legal settlement _ saw no cause for alarm. "Looking back now, of course, it's easy to say I should have asked more questions or maybe been a little more concerned," she told me last fall, sitting in her grassy backyard in Orangeburg, 20 miles north of Manhattan. Branca is a pretty woman, dark and compact, with a winning suburban New York accent. She...