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In her new book Sex Itself: The Search for Male and Female in the Human Genome, Sarah S. Richardson, an assistant professor of the history of science and of studies of women, gender, and sexuality, examines science’s claims to reveal “what is really real about male and female.” Her focus is on the sex chromosomes, the stretches of DNA referred to as X and Y that together determine biological sex in most mammals: individuals with two X chromosomes are female, and those with one X and one Y are male. The sex chromosomes, says Richardson, are “objects of scientific knowledge that have circulated between popular culture and scientific research...