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A review of the 200 or so human embryonic stem cell (hESC) lines approved by the National Institutes of Health (NIH) for federal funding has found a possible ethical problem: Some of the cells may have come from sperm or egg donors who didn't consent to having their cells used in research. University oversight committees should be aware that these cell lines may not meet widely accepted standards, the authors say.

In July 2009, following an order from President Barack Obama, NIH issued guidelines laying out ethical standards that all hESC lines studied with NIH funding must meet. The cell lines must have been derived from surplus embryos donated by couples receiving fertility treatments, for example. But the guidelines don't discuss the possibility that some embryos made have been created using donor eggs or sperm, even though 2005 National Academy of Sciences (NAS) guidelines call for consent from gamete donors. Research administrators at the Rockefeller University in New York City became concerned about this gap last year after a survey suggested that U.S. in vitro fertilization (IVF) clinics usually don't...