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Biologists anticipating a stem-cell gold rush in California will have to wait a little longer, as a string of setbacks is slowing the state_s plans to jump-start such research.

California_s voters agreed last November to bankroll a $3-billion, decade-long initiative for research on stem cells, and backers had hoped that the first research grants would appear by May of this year. But the initiative has come under mounting political and legal fire. Its leaders, facing the daunting task of building a substantial research agency from scratch, now concede that grants won_t begin to go out until autumn, at the earliest.

The stem-cell ballot measure, known as Proposition 71, was drafted by Bob Klein, a property developer whose son suffers from juvenile diabetes. Klein is determined to get money into scientists_ hands as quickly as possible. _We need to do our best with a responsible but aggressive schedule,_ he told Nature in late February.

To minimize red tape, Proposition 71 made supervision of the new agency,the California Institute for Regenerative Medicine (CIRM), the responsibility of a 29-person citizens_ committee. Klein was...