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About Sequencing & Genomics


An organism's genome refers to all the hereditary information encoded in its genes. Sequencing a complete genome, a gene, or a fragment of genetic material involves determining the order of its sub-units: adenine, cytosine, guanine, and thymine.

Scientists are using individuals' genetic sequences to map and catalog human genetic variation in order to improve understanding of human biology, disease susceptibility, and drug response. As costs falls rapidly, the scale and speed of gene sequencing is increasing. The Human Genome Project required thirteen years and $3 billion to sequence the first complete, general human genome. Subsequent projects, such as the International HapMap Project, examined genetic variation between population groups, raising concerns of giving undue biological significance to social categories of race.

Now, the sequencing of complete genomes of specific individuals is becoming almost routine. For example, the Personal Genome Project plans to sequence 100,000 genomes.

Lower prices have also opened the door to companies that offer personal, direct-to-consumer genetic tests.


Hacking life: Scientists ‘recode’ DNA in step toward lab-made organismsby Sharon BegleySTATAugust 18th, 2016Recoded organisms could have talents evolution hasn’t yet created. For instance, they could make proteins that do not exist in nature, including drugs.
CRISPR patent fight: The legal bills are soaringby Sharon BegleySTATAugust 16th, 2016Editas has already spent $10.9M in 2016, but many in the CRISPR field wonder privately why Broad and UC Berkeley have not reached a settlement.
What happens when anyone can edit genes at home? We’re about to find outby Dyllan FurnessDigital TrendsAugust 15th, 2016Scientists express concern about the unintentional consequences of gene editing starter kits proliferating in biohacking communities.
Illumina Would Like You to Sequence More DNA, Pleaseby Sarah ZhangWIREDAugust 15th, 2016The leader of the DNA sequencing market has a start-up accelerator program to find new applications for its technology.
Athletes are keeping their distance from a genetic test for concussion risksby Rebecca RobbinsSTATAugust 15th, 2016Sports competitors, insurers, and researchers are cautious about the privacy and geneticization issues behind testing for "athletic" genes.
Public policy must address technology’s impact[citing CGS' Marcy Darnovsky]by John M. HeinThe Sacramento BeeAugust 13th, 2016“We need to develop habits of mind, or habits of social interaction, that will allow for some very robust public participation on the use of these powerful technologies,” says Marcy Darnovsky.
Ethical questions raised in search for Sardinian centenarians' secretsby Stephanie KirchgaessnerThe GuardianAugust 12th, 2016Samples from residents of Sardinia’s "Blue Zone," who are famed for longevity, have been sold to a for-profit British research firm.
Scientists break 13-year silence to insist 'three-parent baby' technique is safeby Ian JohnstonThe IndependentAugust 11th, 2016The researchers conclude the technique "can produce a viable pregnancy." But the pregnancy they established resulted in miscarriage.
Diversity, disability and eugenics: An interview with Rob Sparrowby Xavier SymonsBioEdgeAugust 11th, 2016Philosophers and the medical profession have been way too swift to make judgments about other people’s quality of life. We're not as far from the bad old eugenics as many think.
The Human Genome Is Having Its Facebook Momentby Whet MoserChicago MagazineAugust 9th, 2016In less than a decade, as many people could have their genomes sequenced as use the social networking site (~1.7 billion monthly users).
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