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About Inheritable Genetic Modification


The Basic Science

Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



CRISPR/Cas Gene-Editing Technique Holds Great Promise, but Research Moratorium Makes Sense Pending Further Study by Jeff Bessen The Conversation July 29th, 2015In the enthusiasm and hype surrounding CRISPR, it is easy to forget that the technology has been in wide use for barely three years and the accompanying risks are not yet known.
The Facts Behind #CRISPRfacts and the Hype Behind CRISPRby Jonathan ChernoguzBiopolitical TimesJuly 28th, 2015WIRED's hyped CRISPR cover article triggered a wave of tweets and criticism.
Cutting-Edge Technology and Mitochondrial Diseases - Where is the Limit?by Dusko IlicBioNewsJuly 27th, 2015In their latest study, Shoukrat Mitalipov and collaborators report on two potential 'gene correction' strategies that can help patients with mitochondrial diseases.
Slipping Into Eugenics? Nathaniel Comfort on the History Behind CRISPRby Elliot HosmanBiopolitical TimesJuly 23rd, 2015A historian unravels the social and political context of genetic research and eugenics in the United States.
Can We Cure Genetic Diseases Without Slipping Into Eugenics?by Nathaniel ComfortThe NationJuly 16th, 2015Gene editing could correct genetic mutations for serious illnesses. Will it also create a new eugenics of personal choice?
Mitochondria Swapby  Kate YandellThe ScientistJuly 15th, 2015Researchers have generated patient-specific induced pluripotent stem cells corrected for mitochondrial defects, but no immediate clinical application is in sight.
Last Scientist in Congress has Human Genetic Engineering Warningby Bill FosterThe HillJuly 8th, 2015"We are on the verge of a technological breakthrough that could change the future of humankind; we must not blindly charge ahead."
Talking About the Germlineby Pete ShanksBiopolitical TimesJuly 8th, 2015The debate about heritable human genetic modification continues, with opinions ranging from enthusiasm to dismay, and strong arguments for political as well as scientific involvement.
Our Focus on the Future Present by Jacob CornInnovative Genomics Initiative blogJuly 6th, 2015At this time, the Innovative Genomics Initiative Lab will not do research on human germline editing for the following several reasons.
Ethics of Gene Editing[with CGS's Marcy Darnovsky]by Betty RollinKQED Religion & Ethics NewsweeklyJuly 2nd, 2015Marcy Darnovsky of the Center for Genetics and Society discusses possible consequences of human germline gene editing for future generations.
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