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About Inheritable Genetic Modification


Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



How to Watch the Biggest Science Story of 2017by Leah LowthorpBiopolitical TimesJanuary 19th, 2017Less than three weeks into the new year, gene editing is already set to be one of the biggest stories of 2017. Here are three key points to watch out for.
How Gene Editing Could Ruin Human Evolution[cites CGS's Marcy Darnovsky]by Jim KozubekTimeJanuary 9th, 2017There are no superior genes. Genes have a long and layered history, and they often have three or four unrelated functions, which balance against each other under selection.
Designer babies: an ethical horror waiting to happen?by Philip BallThe Guardian January 8th, 2017A perfectly feasible 10-20% improvement in health via PGD, added to the comparable advantage that wealth already brings, could lead to a widening of the health gap between rich and poor, both within a society and between nations.
Rewriting the Code of Lifeby Michael SpecterNew YorkerJanuary 2nd, 2017Combining gene drive and CRISPR/Cas9 technologies, Kevin Esvelt is in an unusual position. There has never been a more powerful biological tool, or one with more potential to both improve the world and endanger it.
2016 Fear vs Hope: Gene Editing— Terrible turning point?by Pete ShanksDeccan ChronicleJanuary 1st, 2017As the tools for gene editing rapidly advance, we approach our best chance to prevent the rise of a modern, uncontrolled and dangerously ill-considered techno-eugenics.
Unexpected Risks Found In Replacing DNA To Prevent Inherited Disordersby Jill NeimarkNPRJanuary 1st, 2017Scientists are increasingly concerned that "3-person IVF" techniques may allow flawed mitochondria to resurface and threaten a child's health.
Eugenics warningby Alexandra Minna SternIssues in Science and TechnologyDecember 20th, 2016The eugenic past can be a useful compass when considering present and future uses of genetic technologies.
Gene-editing firms form patent alliance against Editas, Broadby Max StendahlBoston Business JournalDecember 16th, 2016The announcement formalizes a legal coordination and cost-sharing arrangement among four biotech companies.
Babies made from three people approved in UKby James GallagherBBC NewsDecember 15th, 2016Some scientists have questioned the technique, saying it could open the door to genetically-modified 'designer' babies.
Comment on UK Decision to Move Ahead with “3-Person IVF”[Press statement]December 15th, 2016The decision is part of a disturbing trend toward the normalization of an experimental technology that is still widely considered unsafe, and whose implications for future generations are unknown.
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