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About Inheritable Genetic Modification


The Basic Science

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Reproduction 3.0by Leah RamsayBioethics BulletinFebruary 26th, 2015When you use a technology in a new way like this, it really challenges our notions of what it means to be a parent and what it means to be a family.
Mitochondrial Gene Therapy Passes Final U.K. Vote[Quotes CGS's Marcy Darnovsky]by Gretchen VogelScience InsiderFebruary 24th, 2015But some researchers have argued that not enough is known about potential side effects of the technique.
The Truth about Mitochondrial Replacementby Françoise BaylisImpact EthicsFebruary 23rd, 2015Arguments against the popular descriptions of mitochondrial replacement as much needed treatment to avoid the birth of children ‘born to suffer’.
Blog: Three Parent IVFby Dr Trevor StammersSt Mary’s University BlogFebruary 16th, 2015At our current stage of understanding of the interactions between mitochondrial and nuclear DNA, this proposed new therapy could turn out to be a monstrous mistake.
Three Parent Babies: Unethical, Unnecessary, Unsafe by Philippa TaylorBioNewsFebruary 16th, 2015The risks these new experiments hold for the lives and health of human embryos, children and egg donors, and the unprecedented modification of the human germline, together provide a case for not crossing this Rubicon.
Mitochondrial Mission Creep and the Cloning Connection by Pete ShanksBiopolitical TimesFebruary 14th, 2015Shoukhrat Mitalipov wants to use nuclear genome transfer for age-related infertility. He has joined forces with the disgraced stem cell researcher Hwang Woo-suk.
ADF to European Parliament: UK ‘Three-Parent Embryo’ Legislation IllegalGlobal DispatchFebruary 13th, 2015Couples can be helped without tampering with the building blocks of humanity. The issue comes down to fundamental human rights and the constitutional traditions of the member states.
Top 10 Myths About 3-Person IVF Mitochondrial Transferby Paul KnoepflerKnoepfler Lab Stem Cell BlogFebruary 10th, 2015Although well-intentioned, this technology could end up doing far more harm than good, especially if implemented too soon.
Three-Parent Embryos: Medical World Falls Out Over Eggs, Cells and Terminologyby Steve ConnorThe IndependentFebruary 8th, 2015Professor Stuart Newman claims that the commonly used terms are misnomers designed to make it easier for the public to accept the process.
Scientist Who Pioneered 'Three-Parent' IVF Embryo Technique Now Wants to Offer it to Older Women Trying For a Babyby Steve ConnorThe IndependentFebruary 8th, 2015Shoukhrat Mitalipov wants to use "mitochondrial transfer" as a fertility treatment.
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