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About Inheritable Genetic Modification


The Basic Science

Frequently Asked Questions

Arguments Pro & Con

3-Person Embryos

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Medical dilemma of 'three-parent babies': Fertility clinic investigates health of teenagers it helped to be conceived through controversial IVF techniqueby Steve ConnorThe Independent (UK)August 25th, 2014A private fertility clinic in the United States has launched an investigation into the health of 17 teenagers who were born as a result of a controversial IVF technique that produced the world’s first “three-parent” embryos more than 15 years ago.
Should we Open the Door to Genetically Modified Babies?by Jessica CussinsCNBCAugust 11th, 2014There has been a lot of confusion around this controversial issue, but as we are now facing a historic crossroads, it is important to set the record straight.
Huntington Man Deals with Mitochondrial Disease as Preventive Measures Debated[Quotes CGS's Marcy Darnovsky]by Kathleen KerrNewsdayAugust 1st, 2014Neither Tiller nor his mother are convinced that high-tech embryos are the best way to attack mitochondrial disease. She asked, "How do you know what might manifest in the long run?"
Scientists Accuse Government of Dishonesty Over GM Babies in its Regulation of new IVF Technique by Steve ConnorThe IndependentJuly 28th, 2014Leading scientists accuse the UK Government of misleading the public by redefining the term "genetic modification."
Failures and Risks in Biosafety Regulationby Pete ShanksBiopolitical TimesJuly 24th, 2014Accidents at CDC and elsewhere point up the difficulties in regulating potentially dangerous releases of genetically modified organisms, which scientists are, quite responsibly, discussing.
Three Person IVF Plans 'Progress' in UKby Smitha MundasadBBCJuly 22nd, 2014"Looking back 15 years from now in the midst of a designer baby marketplace, people will see this as the moment when the crucial ethical line was crossed."
UK Move Toward “3-Person IVF” is Risky and Premature, Says Public Interest Group[Press statement]July 22nd, 2014The UK Department of Health has announced it will press ahead with efforts to gain Parliamentary approval for three-person IVF.
Procedure to Create Babies with Three People's DNA Could be Legalised in April [UK]by Ian SampleThe Guardian July 22nd, 2014The Department of Health will press ahead with regulations on mitochondrial transfer after public consultation, but several hurdles remain.
Safety Concerns Remain Over Three-Person IVFby Ted MorrowThe GuardianJuly 22nd, 2014There is a lack of data from species more closely related to humans – a gap in our knowledge that would be wise to fill before proceeding to clinical trials.
A Paragraph in Slow Motion: Three-Person IVF in The New York Timesby George Estreich, Biopolitical Times guest contributorJuly 10th, 2014A close look at the rhetoric used to justify experimental technologies, and particularly at the way reasonable objections are dismissed.
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