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About Sequencing & Genomics


An organism's genome refers to all the hereditary information encoded in its genes. Sequencing a complete genome, a gene, or a fragment of genetic material involves determining the order of its sub-units: adenine, cytosine, guanine, and thymine.

Scientists are using individuals' genetic sequences to map and catalog human genetic variation in order to improve understanding of human biology, disease susceptibility, and drug response. As costs falls rapidly, the scale and speed of gene sequencing is increasing. The Human Genome Project required thirteen years and $3 billion to sequence the first complete, general human genome. Subsequent projects, such as the International HapMap Project, examined genetic variation between population groups, raising concerns of giving undue biological significance to social categories of race.

Now, the sequencing of complete genomes of specific individuals is becoming almost routine. For example, the Personal Genome Project plans to sequence 100,000 genomes.

Lower prices have also opened the door to companies that offer personal, direct-to-consumer genetic tests.


Gene Mapping May Not Be for Everyoneby Karen WeintraubUSA TodayAugust 22nd, 2016George Church wants everyone to have their full genome sequenced, but many say we don't know enough about genetics to justify it.
Staying Ahead of Technology’s Curvesby Doug HillBoston GlobeAugust 21st, 2016Embracing new technologies with extraordinary disruptive powers without trying to anticipate and prepare for their potential consequences is now, more than ever, a bad idea.
These New Stem Cell Treatments Are Expensive — and Unprovenby Michael HiltzikLos Angeles TimesAugust 19th, 2016"Stem cells have become a medical buzzword," Paul Knoepfler notes. "I see a lot of businesses using direct marketing to patients to take advantage of that."
Hacking life: Scientists ‘recode’ DNA in step toward lab-made organismsby Sharon BegleySTATAugust 18th, 2016Recoded organisms could have talents evolution hasn’t yet created. For instance, they could make proteins that do not exist in nature, including drugs.
ExAC Project Pins Down Rare Gene VariantsNature EditorialAugust 17th, 2016A new study found only 9 of 192 variants were actually linked to pathogenic disease despite ongoing use in diagnosis and treatment.
In the Fight for Our Genes, Could We Lose What Makes Us Human?by Ziyaad BhoratopenDemocracyAugust 17th, 2016The rapid commercialization of genetics threatens human dignity as our biology is exposed to society's political economy.
CRISPR patent fight: The legal bills are soaringby Sharon BegleySTATAugust 16th, 2016Editas has already spent $10.9M in 2016, but many in the CRISPR field wonder privately why Broad and UC Berkeley have not reached a settlement.
What happens when anyone can edit genes at home? We’re about to find outby Dyllan FurnessDigital TrendsAugust 15th, 2016Scientists express concern about the unintentional consequences of gene editing starter kits proliferating in biohacking communities.
Illumina Would Like You to Sequence More DNA, Pleaseby Sarah ZhangWIREDAugust 15th, 2016The leader of the DNA sequencing market has a start-up accelerator program to find new applications for its technology.
Athletes are keeping their distance from a genetic test for concussion risksby Rebecca RobbinsSTATAugust 15th, 2016Sports competitors, insurers, and researchers are cautious about the privacy and geneticization issues behind testing for "athletic" genes.
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