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About Inheritable Genetic Modification


The Basic Science

Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Scientists solve CRISPR’s ‘Energizer bunny’ problemby Sharon BegleySTATApril 27th, 2016A new CRISPR system called "CORRECT" stopped Cas9 from cutting again and again, and allowed researchers to edit one but not both copies of a target gene.
Editorial: Editing human genes the CRISPR wayby Editorial BoardThe Chicago TribuneApril 27th, 2016Can we trust scientists and governments to set ethical boundaries for research and therapeutic use — and then stick to them? We're skeptical.
God’s Red Pencil? CRISPR and The Three Myths of Precise Genome Editingby Jonathan LathamIndependent Science NewsApril 25th, 2016CRISPR is the latest platform in a 70-year-old "gospel of precision" used to justify moving quickly with new chemical and biological technologies, despite decades of disasters and unintended consequences.
Japanese scientists given green light to modify fertilized human eggs[citing CGS]RT [Russia Today]April 22nd, 2016A government bioethics panel in Japan is only allowing CRISPR gene editing in human embryos for basic research purposes.
Eric Lander talks CRISPR and the infamous Nobel ‘rule of three’by Joel AchenbachThe Washington PostApril 21st, 2016At the Aspen Institute, Lander urged scientific modesty with new gene editing tools: “We are terrible predictors of the consequences of the changes we make.”
Gene-editing research in human embryos gains momentumby Ewen CallawayNature NewsApril 19th, 2016Experiments are now approved in Sweden, China and the United Kingdom.
In IVF, Questions About ‘Mosaic’ Embryosby Kira PeikoffThe New York TimesApril 18th, 201620% of embryos have both "normal" and "abnormal" cells, generating false positive genetic test results, and questions among fertility clinics about whether to implant.
GMOs 2.0: Reengineering Life, from Plants to PeopleWebcast - April 14, 2016 An online discussion about the new generation of genetic modification techniques, and the social issues they raise.
‘It’s most ... most likely use, is the technology of human enhancement’: Chinese scientists alter genes in human embryos in controversial studyby Ben Westcott and Zhuang PinghuiSouth China Morning PostApril 13th, 2016A research team in China has published only the second such paper on genetic engineering in human embryos.
Identity, disability and the genomeby Felicity BoardmanBioNewsApril 11th, 2016It is vital that the voices of families living with the very genetic diseases to be targeted by germline gene editing are heard--it is their lives and stories that offer us the most valuable insights into what we stand to lose.
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