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About Inheritable Genetic Modification


The Basic Science

Frequently Asked Questions

Arguments Pro & Con

3-Person Embryos

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Procedure to Create Babies with Three People's DNA Could be Legalised in Aprilby Ian SampleThe Guardian July 22nd, 2014Government to press ahead with regulations on mitochondrial transfer after public consultation, but several hurdles remain.
Safety Concerns Remain Over Three-Person IVFby Ted Morrow The GuardianJuly 22nd, 2014Using mitochondrial replacement therapy to create embryos with DNA from three people could have serious consequences.
A Paragraph in Slow Motion: Three-Person IVF in The New York Timesby George Estreich, Biopolitical Times guest contributorJuly 10th, 2014A close look at the rhetoric used to justify experimental technologies, and particularly at the way reasonable objections are dismissed.
Mom's Environment During Pregnancy can Affect her Grandchildrenby Jocelyn KaiserScienceJuly 10th, 2014The finding offers some of the strongest evidence yet that a mother’s environment during pregnancy can alter the expression of DNA in ways that are passed on to future generations.
We're Already Designing Babies[With CGS's Marcy Darnovsky]by Olga KhazanThe AtlanticJuly 3rd, 2014Even today, parents are selecting for the traits they want in their offspring. But how far should the genetic tailoring go?
Should We Design Our Babies? [VIDEO] [With CGS's Marcy Darnovsky]The Aspen InstituteJuly 2nd, 2014At the Aspen Ideas Festival, Marcy Darnovsky and Nita A. Farahany discuss the possibility and implications of "designer babies."
The Brave New World of Three-Parent I.V.F.[Quotes CGS's Marcy Darnovsky]by Kim TingleyNew York Times MagazineJune 27th, 2014The historic nature of the moment has turned the technique into a symbol, a red line separating humanity from a dystopian or progressive future, depending on how you look at it.
Seralini Republished: Roundup-Ready GMO Maize Causes Serious Health Damageby Oliver TickellThe EcologistJune 25th, 2014A scientific study has been republished following its controversial retraction under strong commercial pressure.
Selling the Next False Hope? How Experimental IVF Techniques Could be Legalized Despite Increasing Evidence of Potential Harmby Jessica CussinsBiopolitical TimesJune 24th, 2014Contrary to official reports, new evidence shows that “3-person IVF” could pose serious risks to women and children. So why are we being told that it’s a “not unsafe” option?
Three Parents and a Baby - Scientists Advise Caution with Regard to Artificial Insemination MethodHealth CanalJune 18th, 2014One mitochondrial type may be able to assert itself against the other. If the assertive one happens to carry the defective mtDNA, the benefit of the therapy would be jeopardized.
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