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About Inheritable Genetic Modification


The Basic Science

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



Key Questions About the Social and Ethical Implications of Nuclear Genome Transfer or “3-Person IVF” Techniquesby Jessica CussinsBiopolitical TimesJanuary 22nd, 2015As the Institute of Medicine launches an official assessment over the next year, here are eight questions to consider.
Institute of Medicine to Study the Social Policy and Ethics of “3-Person IVF”by Jessica CussinsBiopolitical TimesJanuary 22nd, 2015The FDA held a public meeting last year to assess the safety and efficacy of nuclear genome transfer for the prevention of transmission of mitochondrial diseases. Now it has asked the Institute of Medicine to consider the social and ethical issues.
UK May Be Poised for “Historic Mistake” on “3-Person IVF”by Jessica CussinsBiopolitical TimesJanuary 22nd, 2015A Parliamentary vote is expected as soon as February.
'Designer Babies' Debate Should Start, Scientists Sayby James GallagherBBC NewsJanuary 18th, 2015New gene editing techniques make "designer babies" more feasible, but that does not mean it's inevitably the way we have to go as a society.
Three-Parent Baby Pioneer Jamie Grifo: ‘The Brits Will be Ahead of the World’by Steve ConnorThe IndependentJanuary 16th, 2015A fertility doctor insists his "three-parent embryo" technique is safe, even though the woman who became pregnant with twins using it lost both babies.
New Three-Parent Baby Law ‘is Flawed and Open to Challenge’, says Senior Lawyerby Steve ConnorThe Independent [UK]January 14th, 2015The UK Government’s attempt to legalise so-called “three parent” babies is open to challenge by judicial review, warns international law expert Daniel Brennan.
The Future of Conceptionby Jessica CussinsBiopolitical TimesJanuary 8th, 2015Numerous writers took advantage of the ending year to look broadly at just how drastically we are changing the process of baby-making, and what it all means for society.
Biopolitical News of 2014by Pete Shanks, Jessica Cussins & Marcy DarnovskyBiopolitical TimesDecember 19th, 2014This is everything important that happened in biopolitics in 2014 (or close to it).
Top Biopolitical Times Posts of 2014by Jessica Cussins & Pete ShanksBiopolitical TimesDecember 18th, 2014In 2014, CGS staffers and contributors posted 107 blogs in Biopolitical Times. These are twelve of our favorites.
Rules for Babies 'From Three People'by James GallagherBBCDecember 17th, 2014With the regulations now finalized, MPs will soon vote on whether to make the UK the only country in the world to legalize a form of human germline modification.
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