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About Inheritable Genetic Modification


The Basic Science

Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.



[UK] Calls for IVF laws to be changed to take advantage of gene editing technique by Steve ConnorThe IndependentSeptember 2nd, 2015UK medical research funders issue joint statement "human genome-editing research should proceed," want to push ahead with CRISPR/Cas gene editing in human embyros.
Biohackers Gear Up for Genome Editingby Heidi LedfordNature NewsAugust 26th, 2015DIY labs and synthetic biology "amateurs" are working with cheap and easy-to-use CRISPR gene-editing technology to create novel GM organisms, causing concerns about regulation and safety.
Alphabet/Google Isn’t Evil but Genetically Modifying Mosquitos Might Beby Mic WrightThe Next WebAugust 25th, 2015Recent biotech hype about using gene drive to reduce global malaria is best understood as a new chapter in humanity's historically poor record of forcibly changing ecosystems.
CRISPR: The Latest Biotech Hypeby Anne Fausto-SterlingBoston ReviewAugust 24th, 2015What began with an attempt to build a better yogurt now has journalists speculating about Brave New World scenarios, but the bio-hype relies on a false model of genetic determinism.
Genome Editing: The Age of the Red Pen [References CGS]The EconomistAugust 22nd, 2015Because it is so simple and easy to use, CRISPR has generated huge excitement in the worlds of molecular biology, medical research, commercial biotechnology
Conversation with Kelly Hills: Human Genetic Modification & Bioethicsby Paul KnoepflerKnoepfler Lab Stem Cell BlogAugust 20th, 2015An interview with bioethics commentator Kelly Hills tackles some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable genetic modifications in humans.
What Will 120 Million CRISPR Dollars Buy?by Elliot HosmanBiopolitical TimesAugust 13th, 2015As Editas Medicine receives major injection of financing, how will the genetics boom impact funding for public health?
It's Time for an Uncomfortable Discussion about What it Really Means to Engineer a 'Better Baby'[Australia] by Kevin LoriaBusiness Insider [Australia]August 13th, 2015“Humans have more flaws than we know what to do with ... One of them is that we don’t know what it would mean to make a better baby.”
Exciting CRISPR-Powered “Gene Drive” Also Has Scientists Deeply Concernedby Paul KnoepflerKnoepfler Lab Stem Cell BlogAugust 12th, 2015While potential heritable genetic modification via CRISPR is generating substantial discussion, gene drive warrants increased attention because of its broad power and self-propagating nature.
Putting Ourselves in Harm's Way: Thoughts on Pinker and the Role of Bioethicsby Nathaniel Comfort, Biopolitical Times guest contributorAugust 12th, 2015Nathaniel Comfort confronts Steven Pinker and the legacy of biomedicine, arguing ethicists and historians need to "get in harm's way to spare harm to others."
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