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About Inheritable Genetic Modification

The Basic Science

Human Germline Gene Editing

Frequently Asked Questions

Arguments Pro & Con

3-Person IVF

Inheritable genetic modification (IGM, also called germline engineering) means changing the genes passed on to future generations. The genetic changes would be made in eggs, sperm or early embryos; modified genes would appear not only in the person who developed from that gamete or embryo, but also in all succeeding generations. IGM has not been tried in humans. It would be by far the most consequential type of genetic modification as it would open the door to irreversibly altering the human species.

Proposals for inheritable genetic modification in humans combine techniques involving in vitro fertilization (IVF), gene transfer, stem cells and research cloning.

CRISPR-Cpf1: Hype by Association by Elliot HosmanOctober 2nd, 2015Amid Nobel Prize predictions for CRISPR-Cas9 research, a new CRISPR associated protein takes the media and science community by storm, even as its utility remains unclear.
Gene-edited 'micropigs' to be sold as pets at Chinese instituteby David CyranoskiNature NewsSeptember 29th, 2015The pigs were originally engineered as models for human disease to test expensive drugs in smaller quantities, but the excitement for customizable pets may be serving as a distraction from synthetic biology's more pressing concerns and controversies.
Scientists Find Gene Editing with CRISPR Hard to Resist[quotes Marcy Darnovsky and Pete Shanks]by Cameron ScottHealthlineSeptember 29th, 2015CRISPR, a new technique for editing DNA, is so cheap and easy to use, we may be genetically engineering human embryos before we have time to decide if we should.
New CRISPR Protein Slices through Genomes, Patent Problemsby Antonio RegaladoMIT Technology ReviewSeptember 25th, 2015With patent rights and Nobel Prize announcements pending, Feng Zhang at the Broad Institute reports new CRISPR gene editing enzyme Cpf1 to compete with the hyped CRISPR-Cas9 system.
What If Tinder Showed Your IQ?by Dalton ConleyNautilusSeptember 24th, 2015In a future society where human genetic engineering is pervasive, humans are like a mono-culture staple crop, and screening embryos for desirable traits is a trade-off governed more by politics than health concerns.
Considering CRISPR: Putting a thumb on the scale?by Pete ShanksBiopolitical TimesSeptember 24th, 2015The National Academies have announced the date for their International Summit on Human Gene Editing. Are some of the organizers trying to predetermine the outcome?
The hidden risks for 'three-person' babiesby Garry HamiltonNature NewsSeptember 23rd, 2015"There's a definite possibility you'd see things like disrupted fertility function, various forms of metabolic syndromes and changes in things that relate to metabolism in general."
CRISPR Democracy: Gene Editing and the Need for Inclusive Deliberationby J. Benjamin Hurlbut, Krishanu Saha, & Sheila JasanoffIssues in Science and TechnologySeptember 21st, 2015CRISPR raises basic questions about the rightful place of science in governing the future in democratic societies.
British scientists seek to edit the genes of embryos; bioethicists warn of potential dangers[cites CGS's Marcy Darnovsky]by Ariana Eunjung ChaWashington PostSeptember 18th, 2015In a "troubling and provocative move," UK researchers have applied to genetically modify human embryos, short-circuiting a nascent international conversation.
Center for Genetics and Society comments on First Application to Pursue Genome Editing Research in Human Embryos[Press statement]September 18th, 2015"If scientists and the regulatory agency in the UK are serious about responsible use of powerful new gene altering technologies, they won't be rushing ahead in ways that could open the door to genetically modified humans."
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