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In the first decision in California to address a dispute over the fate of frozen embryos after a couple’s divorce, a state judge in San Francisco on Wednesday ordered the destruction of five embryos after a man challenged his ex-wife’s right to use them.

The woman, Mimi C. Lee, a 46-year-old cancer survivor, argued that she would not have another chance to bear biological children. But in 2010, when she and her husband at the time, Stephen Findley, took part in in vitro fertilization, they signed an agreement that the embryos would be destroyed if they ever divorced.

Judge Anne-Christine Massullo of San Francisco Superior Court upheld the agreement.

“Decisions about family and children often are difficult, and can be wrenching when they become disputes,” Judge Massullo wrote. “The policy best suited to ensuring that these disputes are resolved in a cleareyed manner — unswayed by the turmoil, emotion and accusations that attend to contested proceedings in family court — is to give effect to the intentions of the parties at the time of the decision at...