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For 2 1/2 years, Sara Karklins tried very, very hard to get pregnant. In the fall of 2010, she began the process of in-vitro fertilization – an embryo was formed in a fertility clinic, then implanted into her uterus. The process required megadosing with six times the amount of estrogen given to menopausal women, in order to build up her uterine lining. For three days before each embryo transfer, she also received progesterone injections, which left her buttock muscles swollen, itchy and bruised. Her mood swings were sharp and unpredictable.

Again and again, the embryos failed to attach to Karklins’s uterus. Her fertility doctors injected a blood thinner into her stomach every day to increase blood flow to the uterus. Twice, she took an immunosuppressant to try and stop her body’s rejection of the embryos. The result was a serious respiratory infection, as well as another pregnancy failure.

Karklins, now 32, wasn’t trying to have a baby for herself – she and her then-husband already had two children. The never-ending schedule of pills, needles and doctor’s appointments was...