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The world's largest project to unravel the mysteries of the human brain has been thrown into crisis with more than 100 leading researchers threatening to boycott the effort amid accusations of mismanagement and fears that it is doomed to failure.

The European commission launched the €1.2bn (£950m) Human Brain Project (HBP) last year with the ambitious goal of turning the latest knowledge in neuroscience into a supercomputer simulation of the human brain. More than 80 European and international research institutions signed up to the 10-year project.

But it proved controversial from the start. Many researchers refused to join on the grounds that it was far too premature to attempt a simulation of the entire human brain in a computer. Now some claim the project is taking the wrong approach, wastes money and risks a backlash against neuroscience if it fails to deliver.

In an open letter to the European commission on Monday, more than 130 leaders of scientific groups around the world, including researchers at Oxford, Cambridge, Edinburgh and UCL, warn they will boycott the project and urge...