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In 2009 the San Francisco police arrested Lily Haskell when she allegedly attempted to come to the aid of a companion who had already been taken into custody during a peace demonstration. The authorities released her quickly, without pressing charges. But a little piece of Haskell remained behind in their database.

Haskell is one of hundreds of thousands who have had their DNA extracted as part of an enormous expansion of what were once categorized as criminal data banks. Police in about 25 states and federal agents are now empowered to take a DNA sample after arresting, and before charging, someone. This practice occurs even though many of those in custody are never found guilty. If they are cleared, their DNA stays downtown, and they must undergo a cumbersome procedure to clear their genetic records.

Courts nationwide are now wrestling with the civil-liberties implications. Some have held that the practice violates the Fourth Amendment protection against “unreasonable searches and seizures.” Other courts, including one that heard a legal challenge brought by Haskell, have agreed with law-enforcement officials that lifting DNA...