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Bay Area universities and research groups are betting they can spawn a new generation of medical breakthroughs and the next growth engine for the region's biotechnology industry.

The University of California, San Francisco, later this year plans to open a $123 million stem-cell lab at the foot of Mt. Sutro. The building follows the March launch of the UC Davis's new stem-cell center. Not to be outdone, Stanford University this month is expected to complete a $200 million stem-cell facility.

These are the biggest Greater Bay Area beneficiaries so far of Proposition 71, the 2004 ballot initiative that approved $3 billion in general obligation bonds to be spent over 10 years on stem-cell research in California. While the initiative-an end-run around the Bush administration's now-lifted ban on federal funding of embryonic stem cell research-was initially held up as religious groups and others fought to stop it in the courts, the bond issue got under way and has pumped more than $1 billion into California universities and research groups.

The state's support in turn attracted private donations from California philanthropists. Stanford's...