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CHICAGO - Turning off a gene that has been associated with Alzheimer's disease made mice smarter in the lab, researchers said on Sunday in a finding that lends new insight on learning and may lead to new drugs for memory problems.
They said these mice were far more adept at sensing changes in their environment than their mouse brethren.
"It's pretty rare when you can make an animal smarter," said Dr. James Bibb, assistant professor of psychiatry at the University of Texas Southwestern Medical Center, who led the study published in the journal Nature Neuroscience.
Bibb and colleagues used genetic engineering techniques to breed mice that could be manipulated to switch off Cdk5, a gene that controls production of a brain enzyme linked to diseases marked by the death of neurons in the brain, such as Alzheimer's.
"Any time we're losing neurons, Cdk5 may be contributing to that process. That has made it an area of great interest," Bibb said in a telephone interview.
"We have shown that we can turn off a gene in an adult animal. That has...